Just one poliovirus left to go?

Complaints that just refuse to go away.

More than one way to go.

D ramatic changes accompany the death of cells. Attempts to align these changes into cognate groups and identify the mechanisms responsible for them have led to substantial and sometimes surprising insights into cell biology. One such constellation of structural and functional changes is associated with apoptosis (a death process found in development, atrophy, the targets of cell killing by the...

Forbidding Just One Intersection

Following a conjecture of P. Erdos, we show that if 9 is a family of k-subsets of an n-set no two of which intersect in exactly I elements then for k 2 21+ 2 and n sufficiently large IF:/ < (;:‘,I:) with equality holding if and only if 9 consists of all the k-sets containing a fixed (I+ I)-set. In general we show 19) <dknmax(‘.k-‘-l), where dk is a constant depending only on k. These results ar...

Just One Brain Activity

The term brain activity refers to a wide range of mental faculties that can be assessed either on anatomical/functional micro-, mesoand macrospatiotemporal scales of observation, or on intertwined levels with mutual interactions. Here we show, based on novel topological findings, how every brain activity encompassed in a given anatomical or functional level necessarily displays a counterpart in...

One hundred years of poliovirus pathogenesis.

Poliovirus was first isolated nearly 100 years ago in a landmark experiment that established the viral etiology of poliomyelitis. This discovery stimulated investigation of the pathogenesis of poliomyelitis in many laboratories. Nearly 50 years later, when two effective poliovirus vaccines were developed, the impetus to study poliovirus pathogenesis waned. The identification of the cell recepto...